Faculty and Research

Petes Lab Members


Wei Song
Postdoctoral Associate

375 CARL Bldg
Box 3054 DUMC
Durham, N.C. 27710

Phone: 919.684.5904
Fax: 919.684.6033
Email: wei.song@duke.edu

Wei Song

I received my PhD training in Molecular Medicine with Dr. Alan Tomkinson at the University of Maryland, where I conducted research on the role of human DNA replication and repair proteins in regulating genomic stability. Subsequently, I joined Dr. Tom Petes’s laboratory at Duke University for my postdoctoral research training in Molecular Genetics. At Duke, I have been further pursuing my interests in exploring mechanisms of genomic instability and carcinogenesis. My research projects here focus on identifying chromosomal fragile sites and their relationship with the deficiency of the DNA replication enzyme, DNA polymerase alpha.

Prior to coming to the U.S., I received training in Clinical Medicine (Nephrology) in China. Through eight years of intense medical training, I developed a strong interest in understanding the fundamental mechanisms of diseases. This interest was the primary reason I pursued research training in Molecular Medicine in the U.S. I enjoy devoting my efforts each day to understanding more about diseases in both clinical and scientific contexts.

I am currently supported by the Molecular Mycology and Pathogenesis Training Program (T32-AI52080) from the NIH. 


Publications (selected)


Song W, Gawel M, Dominska M, Greenwell PW, Hazkani-Covo E, Bloom K, Petes TD. Non-random distribution of interhomolog recombination events induced by breakage of a dicentric chromosome in Saccharomyces cerevisiae. Genetics. 2013, 194:1-13 (Featured on Saccharomyces Genome Database; Selected as journal Highlight)

Song W, Petes TD. Haploidization in Saccharomyces cerevisiae induced by a deficiency in homologous recombination. Genetics. 2012, 191:279-284 (Selected as journal Highlight)

Song W, Pascal JM, Ellenberger T, Tomkinson AE. The DNA binding domain of human DNA ligase I interacts with both nicked DNA and the DNA sliding clamps, PCNA and hRad9-hRad1-hHus1. DNA Repair. 2009, 8(8):912-9.

Song W, Levin DS, Varkey J, Post S, Bermudez VP, Hurwitz J, Tomkinson AE. A conserved physical and functional interaction between the cell cycle checkpoint clamp loader and DNA ligase I of eukaryotes. Journal of Biological Chemistry. 2007, 282(31):22721-30.

 

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