Faculty and Research

Alejandro Aballay, PhD
Associate Professor
Director, Center for Host-Microbial Interactions
research  biography • lab members • publications lab website

Representative Publications:

(Complete list of publications on PubMed)

  • Head, B. and Aballay, A. (2014). Recovery from an acute infection in C. elegans requires the GATA transcription factor ELT-2. PLOS Genetics Oct 23. doi:10.1371/journal.pgen.1004609. [Abstract][Full Article as PDF]

  • Cai, Y., Cao, X., Aballay A. (2014). Whole-animal chemical screen identifies colistin as a new immunomodulator that targets conserved pathways. MBio. Aug 12;5(4). pii: e01235-14. doi: 10.1128/mBio.01235-14. [Abstract] [Full Article as PDF]
  • Aballay, A. (2013). Role of the nervous system in the control of proteostasis during innate immune activation: Insights from C. elegans. PLoS Pathog, Aug 9(8): e1003433. [Abstract] [Full Article as PDF]

  • Sun J., Liu Y, Aballay A. (2012). Organismal regulation of XBP-1-mediated unfolded protein response during development and immune activation. EMBO Rep, Aug 31;13(9):855-60. Epub 2012 Jul 13. [Abstract] [Full Article as PDF] [Read Review

  • Singh, V. and Aballay, A. (2012). ER stress pathway required for immune homeostasis is neurally controlled by arrestin-1. J Biol Chem,, Epub ahead of print Aug 8. [Abstract] [Full Article as PDF

  • Sun, J., Singh, V., Kajino-Sakamoto, R., and Aballay, A. (2011). Neuronal GPCR controls innate immunity by regulating non-canonical unfolded protein response genes. Science, Epub 2011 April 7. [Abstract] [Full Article as PDF] [Read Review

  • Means, T.K. and Aballay, A. (2011). Models to study ancient host-pathogen interactions: lessons from Crete. EMBO Rep, 12(1):5-7. [Abstract] [Full Article as PDF

  • Bolz, D.D., Tenor, J.L., and Aballay, A. (2010). A conserved PMK-1/p38 MAPK is required inCaenorhabditis elegans tissue-specific immune response to Yersinia pestis infection. J Biol Chem,285:10832-10840. [Abstract] [Full Article as PDF]

  • Singh, V. and Aballay, A. (2009). Regulation of DAF-16-mediated innate immunity in Caenorhabditis elegansJ Biol Chem, 284:35580-35587. [Abstract][Full Article as PDF

  • Fuhrman, L.E., Kumar Goel, A., Smith, J., Shianna, K.V., Aballay, A. (2009). Nucleolar proteins suppressC. elegans innate immunity by inhibiting p53/CEP-1. PLoS Genetics, 5: e1000657. doi:10.1371/journal.pgen.1000657. [Abstract] [Full Article as PDF]

  • Styer, K.L., Singh, V., Macosko, E., Steele, S.E., Bargmann, C.I., and Aballay, A. (2008)Innate immunity in Caenorhabditis elegans is regulated by neurons expressing NPR-1/GPCR. Science, 17:460-464.[Abstract] [Full Article as PDF] [Get a Review]
  • Haskins, K.A., Russell, J.F., Gaddis, N., Dressman, H.K., and Aballay, A. (2008). Unfolded protein response genes regulated by CED-1 are required for Caenorhabditis elegans innate immunity. Dev Cell, 15:87-97. [Abstract] [Full Article as PDF] [Get a Review]
  • Tenor, J.L., and Aballay, A. (2008). A conserved Toll-like receptor is required for Caenorhabditis elegans innate immunity. EMBO Reports, 9:103-109. [Abstract] [Full Article as PDF]

  • Fuhrman, L.E., Shianna, K.V., Aballay, A. (2008). High-throughput isolation and mapping of C. elegans mutants susceptible to pathogen infection. PLoS One, 6:e2882. [Abstract] [Full Article as PDF]
  • Styer, K.L., Click, E.M., Hopkins, G.W., Frothingham, R., and Aballay, A. (2007). Study of the role of CCR5 in a mouse model of intranasal challenge with Y pestisMicrobes and Infection, 9:1135-1138.[Abstract] [Full Article as PDF]

  • Singh, V. and Aballay, A. (2006). A heat-shock factor HSF-1 response pathway is important forCaenorhabditis elegans immunity against Pseudomonas aeruginosaProc Natl Acad Sci USA, 103:13092-13097. [Abstract] [Full Article as PDF]
  • Singh, V. and Aballay, A. (2006). Heat shock and genetic activation of HSF-1 enhance immunity to bacteria. Cell Cycle, 5:2443-2446. [Abstract] [Full Article as PDF]

  • Burton, E.A., Pendergast, A.M., and Aballay, A. (2006). The Caenorhabditis elegans ABL-1 tyrosine kinase is required for Shigella flexneri pathogenesis. Appl Environ Microbiol, 72:5043-51. [Abstract][Full Article as PDF]
  • Kerry, S., TeKippe, M., Gaddis, N.C., and Aballay, A. (2006). GATA transcription factor required for immunity to bacterial and fungal pathogens. Plos ONE, 1:e77. [Abstract] [Full Article as PDF]

  • Styer, K.L., Hopkins, G.W., Plano, G.V., Frothingham, R., and Aballay, A. (2005). Yersinia pestis killsCaenorhabditis elegans by a biofilm-independent process that involves novel virulence factors.EMBO Reports, 6:992-997[Abstract] [Full Article as PDF]

  • Mylonakis, E. and Aballay, A. (2005). Worms and flies as alternative genetically tractable animal models to study host-pathogen interactions. Infect Immun, 73:3833-3841. [Abstract] [Full Article as PDF]

  • Tenor, J.L., McCormick, B.A., Ausubel, F.M., Aballay, A. (2004). Caenorhabditis elegans-based screen identifies Salmonella virulence factors required for conserved host-pathogen interactions.Curr Biol, 14:1018-1024. [Abstract] [Full Article as PDF]

  • Aballay, A., Drenkard, E., Hilbun, L.R., Ausubel, F.M. (2003). Caenorhabditis elegans innate immune response triggered by Salmonella enterica requires intact LPS and is mediated by a MAPK signaling pathway. Curr Biol, 13:47-52. [Abstract] [Full Article as PDF]

  • Aballay, A and Ausubel, F.M. (2002). Caenorhabditis elegans model system for study of host pathogen interactions. Curr Opin Microbiol, 5:97-101. [Abstract] [Full Article as PDF]

  • Aballay, A. and Ausubel, F.M. (2001). Programmed cell death mediated by ced-3 and ced-4 protectsCaenorhabditis elegans from Salmonella typhimurium-mediated killing. Proc Natl Acad Sci USA,98:2735-2739. [Abstract] [Full Article as PDF]

  • Aballay, A., Yorgey, P., Ausubel, M.A. (2000). Salmonella typhimurium proliferates and establishes a persistent infection in the intestine of Caenorhabditis elegansCurr Biol, 30:1539-1542. [Abstract][Full Article as PDF]
  • Arenas, N.A., Staskevich, A.S., Aballay, A., and Mayorga, L.S. (2000). Intracellular transport ofBrucella abortus in J774 macrophages. Infect Immun, 68:4255-4263. [Abstract] [Full Article as PDF]